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Scientists uncover a signal sent out by the first stars in the universe

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For millions of years after the Big Bang, the universe was a cold place filled with hydrogen and helium created at the dawn of the universe. 

And then, suddenly, there was light.

For the first time, a team of astronomers think they've detected a signal from some of the first stars that formed less than 180 million years after the Big Bang. 

Two new studies published in the journal Nature this week detail new evidence about when those stars formed after the Big Bang. 

SEE ALSO: Mysterious cosmic radio burst spotted in real time from Australia

The new work also opens up questions about those early eons after the universe came to be, and may even reveal cracks in our understanding of physics.  Read more...

More about Space, Stars, Astrophysics, Astronomy, and Cosmology Reported by Mashable 4 hours ago.

South Africa v/s Australia: Aussie skipper Steve Smith plotting Proteas revenge

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Australia are visiting South Africa for four Test series Reported by DNA 4 hours ago.

Neighbours star lands lead role in Hollywood comedy series

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Neighbours star lands lead role in Hollywood comedy series ANOTHER Neighbours alum is ditching Australia for Los Angeles. Reported by Daily Star 4 hours ago.

Stars were active 180 million years after Big Bang

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Stars were active 180 million years after Big Bang Using a radio antenna not much larger than a refrigerator in a remote area of Western Australia, researchers discovered that ancient stars were active within 180 million years after the Big Bang. Reported by MailOnline 4 hours ago.

Evidence of universe's earliest-known stars detected

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WASHINGTON (Reuters) - A ground-based radio antenna in western Australia that resembles a dining room table has detected evidence of the earliest-known stars that illuminated an infant universe shrouded in darkness following its formation in the Big Bang. Reported by Reuters 4 hours ago.

‘Bachelor’ Arie Luyendyk Seen Going For A Run In Australia The Week Before The Big Finale

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Bachelor star Arie Luyendyk was spotted out for a jog in Australia, where he’s currently visiting for a car race. He looked pretty relaxed considering next Monday night the world will find out which bachelorette he chooses to be his wife! Click through to see pics of Arie the week before his big announcement.

The post ‘Bachelor’ Arie Luyendyk Seen Going For A Run In Australia The Week Before The Big Finale appeared first on OK! Magazine. Reported by OK! Magazine 3 hours ago.

Joe And Nick Jonas Have Fun Lawn Bowling In Australia

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This looks fun! Joe and Nick Jonas are clearly having a blast abroad. The two had fun while lawn bowling in Bondi. The brothers are currently in Australia.

The post Joe And Nick Jonas Have Fun Lawn Bowling In Australia appeared first on OK! Magazine. Reported by OK! Magazine 3 hours ago.

American Quilter’s Society Awards over $50,000 to Contest Winners at AQS QuiltWeek® in Daytona Beach, FL

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American Quilter’s Society, the largest quilting membership organization in the world, is pleased to announce the winners of the AQS Quilt Contest. Over $50,000 in prizes will be awarded to the winners at AQS QuiltWeek – Daytona Beach, FL.

DAYTONA BEACH, Fla. (PRWEB) February 28, 2018

American Quilter’s Society, the largest quilting membership organization in the world, is pleased to announce the winners of the AQS Quilt Contest. Over $50,000 in prizes will be awarded to the winners at AQS QuiltWeek – Daytona Beach, FL. The Daytona Beach AQS QuiltWeek® event will run from February 28 to March 3 at the Ocean Center, 101 North Atlantic Avenue, Daytona Beach, FL 32118.

As part of the American Quilter’s Society’s celebration of quilting excellence, the contest recognizes the skill and creativity of today’s quiltmakers, as artists compete in the AQS Quilt Contest for more than $50,000 in cash awards. Entries come from around the world to compete in the contest. This year’s winners come from seventeen different states and eight countries. These winning quilts will astound the 15,000 quilters expected to visit AQS QuiltWeek in Daytona Beach this week:

Best of Show Award
#109    FLEUR DE GLACE, Colette Dumont, Saint-Romain, Quebec, Canada

Best Wall Quilt Award
#506    BLACK PEARL, Aline Bugarin and Natasha Bugarin, Campinas, São Paulo, Brazil

Best Use of Color Award
#313    BETWEEN HEAVEN AND EARTH, Audra Rasnake, Meadowview, VA

Best Original Design Award
#601    MAJESTIC FLIGHT, Joanne Baeth, Bonanza, OR

Best Hand Workmanship Award
#314    AZTEC SUNSET, Linda Roy, Knoxville, TN

Best Stationary Machine Workmanship Award
#107    HARVEST HOME, Janneke de Vries-Bodzinga, Kollumerzwaag, Friesland, Netherlands

Best Movable Machine Workmanship Award
#227    FRACTAL, Claudia Pfeil, Krefeld, North Rhine-Westphalia, Germany

Large Quilts – Stationary Machine Quilted
First        #118    PEAR DROPS, Cheryl Kerestes, Wyoming, PA
Second        #117    DECONSTRUCTED DOILIES, Kat Jones, Chigwell, Tasmania, Australia
Third        #111    CAPTIVATED BY NATURE, Olga Gonzalez-Angulo, Sant Feliu de Guíxols, Spain
Hon. Mention    #119    PALEO PUZZLE, Kimberly Lacy, Colorado Springs, CO

Large Quilts – Movable Machine Quilted
First        #212    TAKING THE UNMAPPED ROAD, Margaret Solomon Gunn, Gorham, ME
Second        #221    STARBURST, Peggy Marquardt, Rhinelander, WI
Third        #213    MOONFLOWER, Molly Y. Hamilton-McNally, Tehachapi, CA
Hon. Mention    #223    YOU KNOW WHAT?, Hiroko Miyama, Azumino, Nagano, Japan

Hand Quilted Quilts
First        #310    THREADS OF FRIENDSHIP (CAROL’S GIFT), Barbara Korengold, Chevy Chase, MD
Second        #304    ESFAHAN, Megan Farkas, Sanbornton, NH
Third        #315    HAWAIIAN IMPROV, Cheryl L. See, Winchester, VA
Hon. Mention    #305    FANTASTIC!, Junko Fujiwara, Narashino City, Chiba, Japan

Wall Quilts – Stationary Machine Quilted
First        #429    NEARLY A 9 PATCH, Laura Welklin, Noblesville, IN
Second        #402    TICKLED PINK, Deb Crine, Marco Island, FL
Third        #423    JUST AROUND THE CORNER, Beth Schillig, Gahanna, OH
Hon. Mention    #418    BEST OF THE NORTHWEST, Kathy McNeil, Tulalip, WA

Wall Quilts – Movable Machine Quilted
First        #509    A FLIGHT OF FANCY, Robyn Cuthbertson, Lower Plenty, Victoria, Australia
Second        #516    AURORA BOREALIS, Peggy Marquardt, Rhinelander, WI
Third        #515    GODS EYE, Karen Marchetti, Port St. Lucie, FL
Hon. Mention    #518    HIGH FLYING, Patti Sandage, Middleton, TN

Wall Quilts – Pictorial
First        #615    OR-7, Christina McCann, Depoe Bay, OR
Second        #623    THREE THIEVING CROWS, Gayle Pulley, Eatonville, WA
Third        #608    I MUST GO DOWN TO THE SEA AGAIN, Leah Gravells, Edmonton, Alberta, Canada
Hon. Mention    #620    THE ARC, Betty Kent New, Stilwell, OK

Wall Quilts – 1st Entry in an AQS Daytona Beach Quilt Contest
First        #708    ENDANGERED—THE LEMUR’S TALE, Maria Ferri Cousins, Great River, NY
Second        #709    REFLECTIONS IN BLUE, Robyn Cuthbertson, Lower Plenty, Victoria, Australia
Third        #728    CONTENTMENT—A 20TH ANNIVERSARY CELEBRATION, Teresa Yielding Rawson, Tuscumbia, AL
Hon. Mention    #721    DAYS END, Peggy Marquardt, Rhinelander, WI

All of the winning quilts, as well as those of the semifinalists, will be on display at the Ocean Center from Wednesday through Saturday. In addition, AQS QuiltWeek will be hosting a number of other special exhibits, workshops with some of the top talent in the quilt industry, and an extensive merchant mall comprised of both local and national vendors.

Admission to AQS QuiltWeek is $14 per day and tickets can be purchased at the door. Multi-day tickets are available. Hours are Wednesday through Friday, from 9:00 a.m. to 6:00 p.m., and Saturday from 9:00 a.m. to 4:00 p.m. Ticket and additional information can be found at quiltweek.com or by calling 1-270-898-7903.

About the American Quilter’s Society

The American Quilter’s Society is the largest quilting membership organization in the world. For more than 30 years, AQS has been the leading voice in quilting inspiration and advice, through a broad suite of products— live events, contests, workshops, online classes and networks, magazines, books, patterns, fabric, and catalogs. At AQS, we believe that with inspiration and advice, the creatively-minded individual can take their quilting projects beyond what even they had imagined. For more information on the American Quilter’s Society, please visit http://www.americanquilter.com or call 270-898-7903. Reported by PRWeb 3 hours ago.

Hockey World Cup: Ireland handed a 'competitive' pool draw

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Hockey World Cup: Ireland handed a 'competitive' pool draw Ireland have been drawn in a 'competitive' pool against Australia, China and England at the 2018 Hockey World Cup in India. Reported by BBC News 3 hours ago.

Asia and Australia Edition: Xi Jinping, Jared Kushner, Brexit: Your Thursday Briefing

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Here’s what you need to know to start your day. Reported by NYTimes.com 3 hours ago.

Banks have a 'big appetite' to join JPMorgan's blockchain party

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Banks have a 'big appetite' to join JPMorgan's blockchain party· *During JPMorgan's investor day, CFO Marianne Lake said the company's blockchain initiative — the Interbank Information Network — was working. *
· *Lake said other banks are looking to "join the party."*

--------------------

JPMorgan and crypto are a pair many might equate to oil and water. 

The Wall Street giant's CEO — Jamie Dimon — famously called bitcoin a "fraud." And in a big regulatory filing the bank noted it could one day be disrupted by cryptocurrencies. 

But the bank has been running a pilot program to make certain payments faster using cryptocurrency technology. And other banks are looking to get in on the action. 

The Wall Street juggernaut launched its so-called Interbank Information Network (IIN) in October 2017 and the firm's chief financial officer Marianne Lake says the initiative is working. The platform, which is built on top of the bank's private Quorom blockchain, allows JPMorgan to exchange information with other banks to address compliance issues in certain cross-border payments, Lake said during the bank's investor day on Tuesday. The pilot involves JPMorgan, Royal Bank of Canada and Australia and New Zealand Banking Group, but Lake said that other banks are looking to "join the party." 

That's not totally surprising considering how difficult cross-border payments can be. The time and expense of such payments is one of the things bitcoin seeks to remedy. A bitcoin holder can send or receive a coin in a matter of minutes, when the network isn't super clogged up. 

"One of the most costly and time-consuming elements of executing cross-border payments today is in correspondent banks having to research and respond to compliance inquiries of each other," Lake said "Today, payments that are flagged for compliance reasons can be delayed for up to two weeks, but this technology can reduce that to minutes."

One crypto-evangelist described the project as an "actually pretty cool use-case."

John-Paul Thorbjorsen, the head of crypto company Canya, told Business Insider the pilot shows JPMorgan has "figured out how to make an entry in the space."

Lake said the IIN is the first of many initiatives the bank will spearhead in payments. 

"The Interbank Information Network represents the first step in our ability to improve end-to-end wholesale payments," Lake said. 

JPMorgan isn't the only bank testing the water with blockchain technology. Barclays, UBS, and Credit Suisse are among the banks that participated in a pilot using Ethereum's blockchain to prepare for Markets in Financial Instruments Directive (MIFID II), a sweeping regulatory overhaul in Europe that went live this year. 

Join the conversation about this story »

NOW WATCH: We asked Jamie Dimon why JPMorgan is forming a new healthcare company with Amazon and Berkshire Hathaway — here's what he said Reported by Business Insider 2 hours ago.

Sport24.co.za | Faf returns for biggest battle of the summer

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Proteas Test captain, Faf du Plessis, returns to lead the squad for the first Test match against Australia starting at Kingsmead in Durban. Reported by News24 2 hours ago.

Great Wines of Italy 2018 US Tour Arrives in New York

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JamesSuckling.com presents master tastings in New York, Miami, Beverly Hills, and San Francisco

NEW YORK (PRWEB) February 28, 2018

JamesSuckling.com presents the Great Wines of Italy US tour, beginning on Tuesday, March 6 at the IAC Building in New York City, featuring Italy’s most sought-after wines from prestigious and renowned Italian brands as well as chosen premium boutique wineries. World-renowned wine critic James Suckling has selected more than 120 wineries to present two of their top wines or new releases with top scores of 90 points and above. The selection will include superb wines from all of Italy, including Brunello, Barolo, a selection of Super Tuscans, Barbaresco, Amarone, Chianti Classico, and many more. Winemakers and owners will be personally in attendance to pour you some of their best wines and discuss what makes them so special at this exclusive walk-around tasting.

The tour includes four events across the United States. For more information, please visit JamesSuckling.com.

New York
March 6, 5-8pm (media & trade preview begins at 4:30pm), IAC Building, 527 W 18th Street

Miami
March 7, 5-8pm (media & trade preview beings at 4:30pm), EAST, Miami, 788 Brickell Plaza

Beverly Hills
March 9, 5-8pm (media & trade preview begins at 4:30pm), Montage, 225 N Canon Drive

San Francisco
March 11, 3-6pm (media & trade preview begins at 2:30pm), Presidio Golden Gate Club, 135 Fisher Loop

For press registration and inquiries, please contact Eleonore Podda (epodda@colangelopr.com) or Josh Zoland (jzoland@colangelopr.com) of Colangelo & Partners.

About JamesSuckling.com:
JamesSuckling.com is a wine media platform and events company founded by esteemed journalist and wine critic James Suckling. The website provides a range of content, from tasting notes and videos to blogs and events that focus on the great wines of the world, including Italy, Bordeaux, Champagne, Australia, New Zealand, California, Chile, and Argentina. CEO and Editor James Suckling believes that today’s wine drinker deserves more than just written reviews and criticism. They need to see with their own eyes the place, the people, and the rating process. James and his team of critics rate about 17,000 wines a year using the 100-point scale. JamesSuckling.com organizes more than a dozen events each year in cities across the United States and Asia for consumers and trade. Reported by PRWeb 1 hour ago.

BeiGene Reports Fourth Quarter and Full Year 2017 Financial Results

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CAMBRIDGE, Mass. and BEIJING, China, Feb. 28, 2018 (GLOBE NEWSWIRE) -- BeiGene, Ltd. (NASDAQ:BGNE), a commercial-stage biopharmaceutical company focused on developing and commercializing innovative molecularly targeted and immuno-oncology drugs for the treatment of cancer, today reported recent business highlights, anticipated 2018 milestones and financial results for the fourth quarter and full year of 2017.“We had a transformative year in 2017, highlighted by the collaboration with Celgene Corporation for our anti-PD1 antibody, tislelizumab, expansion of the commercial team in China, and execution on the development plans that we believe will be critical to realizing the potential of our portfolio compounds in China and globally,” said John V. Oyler, Founder, Chief Executive Officer, and Chairman of BeiGene. “We have now enrolled more than 2,300 patients and healthy subjects worldwide in clinical trials of our investigational agents as of the end of January 2018 and are on target for our first NDA filings in China later this year.”   

“We also strengthened our balance sheet with an $800 million offering this January. This successful financing will support our efforts to further develop our near-term clinical and pipeline programs, as well as continue to build our  development and commercial capabilities to help maximize our opportunities in the rapidly evolving Chinese oncology market,” continued Mr. Oyler.

*Fourth Quarter 2017 and Recent Business Highlights*

*Clinical Programs:*

*Zanubrutinib (BGB-3111)*, an investigational small molecule inhibitor of Bruton’s tyrosine kinase (BTK)

· Presented preliminary clinical data from the Phase 1 trial of zanubrutinib in patients with non-Hodgkin’s lymphoma in an oral presentation at the 59th American Society of Hematology (ASH) Annual Meeting in Atlanta;· Presented updated Phase 1b data for the combination of zanubrutinib and GAZYVA^® (obinutuzumab) in patients with chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL/SLL) and follicular lymphoma (FL) at the ASH annual meeting;· Presented initial Phase 1b data for the combination of zanubrutinib and the Company’s investigational anti-PD-1 antibody, tislelizumab (BGB-A317), in patients with B-cell malignancies at the ASH annual meeting;· Completed enrollment in the Phase 2 pivotal trial in China in patients with CLL/SLL; and· Initiated a Phase 1b/2 trial in China of zanubrutinib in combination with rituximab in patients with diffuse large B-cell lymphoma, FL, and marginal zone lymphoma.

*Tislelizumab (BGB-A317)*, an investigational humanized monoclonal antibody against the immune checkpoint receptor PD-1 under the collaboration with Celgene Corporation

· Presented preliminary results from the Phase 1 trial of tislelizumab in patients with urothelial carcinoma at the 2018 Genitourinary Cancers Symposium;· Presented initial Phase 1b data for the combination of zanubrutinib and tislelizumab in patients with B-cell malignancies at the ASH annual meeting;· Initiated the following trials: 
-- Global Phase 3 trial of tislelizumab in patients with previously untreated advanced hepatocellular carcinoma (HCC); and

-- Global Phase 3 trial of tislelizumab in patients with advanced unresectable or metastatic esophageal squamous cell carcinoma.*Pamiparib (BGB-290)*, an investigational small molecule PARP inhibitor

· Initiated a Phase 2 pivotal trial in China of pamiparib in patients with advanced ovarian cancer.

*BGB-A333*, an investigational humanized monoclonal antibody against the immune checkpoint receptor ligand PD-L1

· Initiated a global Phase 1/2 trial of BGB-A333 monotherapy and in combination with tislelizumab in advanced solid tumors.

*Commercial Products*

· Received approval in China for a new indication for REVLIMID^® (lenalidomide) in combination with dexamethasone as a treatment for adult patients with previously untreated multiple myeloma who are not eligible for transplant; and· Initiated commercialization of VIDAZA^® (azacitidine) in China.

*Corporate Development:*

· Entered an exclusive license agreement with Mirati Therapeutics for the development, manufacturing and commercialization of Mirati’s sitravatinib, an investigational tyrosine kinase inhibitor targeting TAM family receptors (TYRO3, Axl, MER), split family receptors (VEGFR2, KIT) and RET, in Asia (excluding Japan), Australia and New Zealand; and· Entered into a commercial supply agreement for tislelizumab with Boehringer Ingelheim.

*Expected 2018 Milestones*

*Zanubrutinib*

· Present updated Phase 1 and China pivotal trial data;· Submit first NDA in China for mantle cell lymphoma;· Complete enrollment in the global Phase 3 trial for Waldenstrom’s macroglobulinemia in Q3 2018; and· Initiate a global head-to-head Phase 3 trial versus ibrutinib in relapsed/refractory CLL.

*Tislelizumab *

· Present updated Phase 1 data and China pivotal trial data;· Submit first NDA in China for Hodgkin’s lymphoma;· Complete enrollment in the Phase 2 pivotal trial in China for urothelial carcinoma; and· Initiate additional global and China-focused pivotal trials.

*Pamiparib*

· Present updated Phase 1 data;· Initiate a global Phase 3 trial in gastric cancer in 1H 2018; and · Initiate a Phase 3 trial in China as a maintenance therapy in patients with platinum-sensitive recurrent ovarian cancer.

*Commercial Products*

· Expand provincial reimbursement for ABRAXANE^® (nanoparticle albumin-bound paclitaxel) in China.

*Fourth Quarter and Full Year 2017 Financial Results*

*Cash, Cash Equivalents, and Short-Term Investments* were $837.52 million as of December 31, 2017, compared to $757.44 million at September 30, 2017 and $368.17 million at December 31, 2016. This includes approximately $139.50 million of cash, cash equivalents and short-term investments at December 31, 2017, held by our joint venture, BeiGene Biologics, to build a commercial biologics facility in Guangzhou, China and to fund research and development of biologics drug candidates in China. Cash and cash equivalents as of December 31, 2017 do not include the net proceeds raised in the January 2018 public offering.

· The increase of $80.08 million in the in the fourth quarter of 2017 was primarily due to the receipt of $170.95 million from Celgene as part of upfront licensing fees from the tislelizumab collaboration, offset by increased research and development spending and capital expenditures as we continue to advance our pipeline.· The increase of $469.35 million from the prior year period was primarily due to cash received from Celgene from the tislelizumab collaboration, including upfront licensing fees of $263.00 million and an equity investment of $150.00 million, and net proceeds of $188.52 million from our August 2017 follow-on public offering, offset by increased cash used in operations and for capital expenditures.· Capital expenditures for the quarter and year ended December 31, 2017 were $18.93 million and $58.73 million, compared to $8.06 million and $23.50 million, respectively, for the same periods in 2016, primarily attributable to increased investment in our manufacturing facilities in Guangzhou and Suzhou.

*Revenue* for the fourth quarter and year ended December 31, 2017 was $18.17 million and $238.39 million, respectively, compared to nil and $1.07 million in the same periods in 2016, attributable to product and collaboration revenue under the Celgene collaboration.

· Product revenue from sales of ABRAXANE and REVLIMID in China totaled $15.61 million and $24.43 million for the fourth quarter and from August 31, 2017 (the closing of the Celgene transaction) to December 31, 2017, respectively.· Collaboration revenue totaled $2.57 million and $213.96 million for the fourth quarter and year ended December 31, 2017, respectively, reflecting recognition of the upfront licensing fees from Celgene in the third quarter and deferred upfront fees recognized in the fourth quarter. 

*Expenses *for the fourth quarter and year ended December 31, 2017 were $121.97 million and $336.84 million, respectively, compared to $37.27 million and $118.13 million in the same periods in 2016.

· *Cost of sales *for the fourth quarter and from August 31 to December 31, 2017 were $3.03 million and $4.97 million, respectively. Cost of sales relates to the cost of acquiring ABRAXANE and REVLIMID for distribution in China.· *R&D Expenses* for the fourth quarter and year ended December 31, 2017 were $91.34 million and $269.02 million, respectively, compared to $28.93 million and $98.03 million in the same periods in 2016. The increase in R&D expenses was primarily attributable to increased spending on our ongoing late-stage clinical trials, increased manufacturing costs for our drug candidates due to expansion of ongoing clinical programs, and increased employee compensation expense as a result of increased headcount to support our clinical programs. Additionally, R&D-associated share-based compensation expense was $10.95 million and $30.61 million for the fourth quarter and year ended December 31, 2017, respectively, compared to $2.90 million and $8.08 million for the same periods in 2016, due to increased headcount and a higher share price.· *SG&A Expenses *for the fourth quarter and year ended December 31, 2017 were $27.42 million and $62.60 million, respectively, compared to $8.34 million and $20.10 million in the same periods in 2016. The increase in SG&A expenses was primarily attributable to increased headcount, including employees transferred from Celgene China in connection with the license agreement for Celgene’s commercial products in China, as well as higher professional service fees related to the Celgene transaction and patent prosecution activities, and costs to support our growing operations. In addition, SG&A-associated share-based compensation expense was $5.51 million and $12.25 million for the fourth quarter and year ended December 31, 2017, respectively, compared to $1.05 million and $2.55 million for the same periods in 2016.

*Net Loss *for the fourth quarter and year ended December 31, 2017 was $99.28 million and $93.30 million, respectively, compared to a net loss of $37.60 million and $119.22 million in the same periods in 2016.

*Financial Summary*

*Select C**onsolidated** B**alance** S**heet Data (U.S. GAAP)*          
(Amounts in thousands of U.S. Dollars)
(Audited)          
  * * * *      
  * * *December 31, **2017* * * *December 31, 2016**
*
Cash, cash equivalents and short‑term investments $ 837,516 $ 368,174
Working capital   763,509   339,341
Property and equipment, net   62,568   25,977
Total assets   1,046,479   405,813
Total liabilities   362,248   52,906
Noncontrolling interest   14,422   —
Total equity $ 684,231 $ 352,907

*C**onsolidated* *Statements* *of* *Operations (U.S. GAAP)*
(Amounts in thousands of U.S. Dollars, except for number of American Depositary Shares (ADSs) and per ADS data)
   
* * * * *Three Months Ended*
*December 31,*
*(Unaudited)* * * *Twelve Months Ended*
*December 31,*
*(Audited)*
  * * *2017* * * *2016* * * *2017* * * *2016*
Revenue                
Product revenue, net $ 15,606 $ — $ 24,428 $ —
Collaboration revenue   2,568   —   213,959   1,070
Total revenues   18,174   —   238,387   1,070
Expenses                
Cost of sales – products   (3,030)   —   (4,974)   —
Research and development   (91,340)   (28,933)   (269,018)   (98,033)
Selling, general and administrative   (27,415)   (8,337)   (62,602)   (20,097)
Amortization of intangible assets   (187)   —   (250)   —
Total expenses   (121,972)   (37,270)   (336,844)   (118,130)
Loss from operations   (103,798)   (37,270)   (98,457)   (117,060)
Interest (expense) income, net   (527)   47   (4,108)   383
Changes in fair value of financial instruments   —   —   —   (1,514)
Gain (loss) on sale of available-for-sale securities   34   (338)   44   (1,415)
Other income (expense), net   9,926   (289)   11,457   443
Loss before income taxes   (94,365)   (37,850)   (91,064)   (119,163)
Income tax (expense) benefit   (4,915)   252   (2,235)   (54)
Net loss $ (99,280) $ (37,598) $ (93,299) $ (119,217)
Less: Net loss attributable to noncontrolling interest   43   —   (194)   —
Net loss attributable to BeiGene, Ltd. $ (99,323) $ (37,598) $ (93,105)   (119,217)
Net Loss per ADS, basic and diluted $ (2.19) $ (1.05) $ (2.23) $ (3.84)
Weighted-average number of ADSs outstanding – basic and diluted   45,402,681   35,663,284   41,783,497   31,047,650
                 

 *C**onsolidated* *Statements* *of* *Comprehensive Income (Loss) (U.S. GAAP)*
(Amounts in thousands of U.S. Dollars)
* * * *
    *Three Months Ended*
*December 31, *
* (Unaudited)**
*   *Twelve Months Ended *
*December 31,*
* (Audited)**
*
  * * *2017* * * *2016* * * *2017* * * *2016*
Net loss $ (99,280) $ (37,598) $ (93,299) $ (119,217)
Other comprehensive (loss) income, net of tax of nil:                
Foreign currency translation adjustments   (134)   (232)   851   (245)
Unrealized holding gain, net   (354)   251   (296)   1,108
Comprehensive loss   (99,768)   (37,579)   (92,744)   (118,354)
Less: Comprehensive loss attributable to noncontrolling interests   73   —   (105)   —
Comprehensive loss attributable to BeiGene, Ltd. $ (99,841) $ (37,579) $ (92,639) $ (118,354)
                 

*About BeiGene*

BeiGene is a global, commercial-stage, research-based biotechnology company focused on molecularly targeted and immuno-oncology cancer therapeutics. With a team of over 900 employees in China, the United States, and Australia, BeiGene is advancing a pipeline consisting of novel oral small molecules and monoclonal antibodies for cancer. BeiGene is also working to create combination solutions aimed to have both a meaningful and lasting impact on cancer patients. BeiGene markets ABRAXANE^® (nanoparticle albumin–bound paclitaxel), REVLIMID^® (lenalidomide), and VIDAZA^® (azacitidine) in China under a license from Celgene Corporation.^i

*Forward-Looking Statements*

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 and other federal securities laws, including statements regarding BeiGene’s advancement of, and anticipated clinical development, regulatory milestones and commercialization of its drugs and drug candidates, the potential for the Company’s drugs and drug candidates, and the expected milestones under the caption “Expected 2018 Milestones”. Actual results may differ materially from those indicated in the forward-looking statements as a result of various important factors, including BeiGene's ability to demonstrate the efficacy and safety of its drug candidates; the clinical results for its drug candidates, which may not support further development or marketing approval; actions of regulatory agencies, which may affect the initiation, timing and progress of clinical trials and marketing approval; BeiGene's ability to achieve commercial success for its marketed products and drug candidates, if approved; BeiGene's ability to obtain and maintain protection of intellectual property for its technology and drugs; BeiGene's reliance on third parties to conduct drug development, manufacturing and other services; BeiGene’s limited operating history and BeiGene's ability to obtain additional funding for operations and to complete the development and commercialization of its drug candidates, as well as those risks more fully discussed in the section entitled “Risk Factors” in BeiGene’s most recent quarterly report on Form 10-Q, as well as discussions of potential risks, uncertainties, and other important factors in BeiGene's subsequent filings with the U.S. Securities and Exchange Commission.  All information in this press release is as of the date of this press release, and BeiGene undertakes no duty to update such information unless required by law.

*Investor Contact                         *
Lucy Li, Ph.D.
+1 781-801-1800
ir@beigene.com

*Media Contact*
Liza Heapes 
+ 1 857-302-5663 
media@beigene.com

--------------------

^i ABRAXANE^®, REVLIMID^®, and VIDAZA^® are registered trademarks of Celgene Corporation. GAZYVA^® is a registered trademark of Genentech. Reported by GlobeNewswire 1 hour ago.

K2M Group Holdings, Inc. Reports Fourth Quarter and Full Year 2017 Financial Results

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LEESBURG, Va., Feb. 28, 2018 (GLOBE NEWSWIRE) -- K2M Group Holdings, Inc. (Nasdaq:KTWO) (the “Company” or “K2M”), a global leader of complex spine and minimally invasive solutions focused on achieving three-dimensional Total Body Balance™, today reported financial results for its fourth quarter and fiscal year ended December 31, 2017. *Fiscal Year 2017 Financial Summary:*

· Total fiscal year 2017 revenue of $258.0 million, up 9% year-over-year on both a reported basis and on a constant currency basis.
· Domestic fiscal year 2017 revenue of $197.3 million, up 9% year-over-year, comprised of:

· U.S. Complex Spine growth of 8% year-over-year
· U.S. Minimally Invasive Surgery (MIS) growth of 16% year-over-year
· U.S. Degenerative growth of 8% year-over-year

· International fiscal year 2017 revenue of $60.7 million, up 9% year-over-year, or 10% on a constant currency basis.
· Net loss of $37.1 million for fiscal year 2017, compared to a net loss of $41.7 million in prior year.
· Adjusted EBITDA loss of $0.7 million for fiscal year 2017, compared to Adjusted EBITDA of $1.4 million in the prior year.

*Fourth Quarter 2017 Financial Summary:*

· Total fourth quarter revenue of $67.8 million, up 10% year-over-year on a reported basis and 9% on a constant currency basis.
· Domestic fourth quarter revenue of $51.9 million, up 9% year-over-year, comprised of:

· U.S. Complex Spine growth of 12% year-over-year
· U.S. Minimally Invasive Surgery (MIS) growth of 11% year-over-year
· U.S. Degenerative growth of 6% year-over-year

· International fourth quarter revenue of $15.9 million, up 13% year-over-year, and 10% on a constant currency basis.
· Net loss of $8.7 million for the fourth quarter, compared to a net loss of $12.5 million in the comparable quarter last year.
· Adjusted EBITDA loss of $1.9 million for the fourth quarter, compared to Adjusted EBITDA loss of $28,000 in the comparable quarter last year.

*Fourth Quarter Product Introductions and Strategic Highlights:*

· On October 4, 2017, the Company announced that President and Chief Executive Officer Eric Major had been elected Chairman of the Company's Board of Directors, effective immediately. Major succeeded Dan Pelak, who assumed the role of Independent Lead Director after serving as Chairman since 2010.  
· On October 23, 2017, the Company announced that it has acquired from Cardinal Spine, a privately held medical device company, the PALO ALTO^® Cervical Static Corpectomy Cage System. PALO ALTO, a cervical vertebral body replacement device, is the first and only static corpectomy cage in the world to receive a cervical 510(k) clearance from the FDA. In addition to PALO ALTO, K2M has also acquired the associated intellectual property and product inventory. 
· On October 25, 2017, the Company announced a global compatibility and co-marketing agreement with Brainlab. The two companies will collaborate in the commercial release of future navigated K2M spinal systems, which would be compatible with Brainlab spinal navigation systems.
· On November 30, 2017, the Company announced the completion of 300 surgical cases using the RHINE™ Cervical Disc System*. The RHINE Cervical Disc System* is an artificial disc replacement that features a one-piece compressible polymer core design with dome-shaped, plasma-coated endplates and a central-split keel.
· On December 20, 2017, the Company announced that it received a CE Mark for its CAPRI® Cervical 3D Expandable Corpectomy Cage System* featuring Lamellar 3D Titanium Technology™ and the successful completion of its first surgical case.  * These products are intended for export and not sold or offered for sale in the United States.

"Our financial results for calendar year 2017 reflect total revenue growth of approximately 9% year-over-year, above the high-end of our guidance range," said Chairman, President, and Chief Executive Officer, Eric Major. "We delivered approximately 9% growth in the United States in 2017—well above-market growth rates—driven by solid execution against our strategic goal of increasing market share by introducing new and innovative spinal implant solutions and expanding our distribution footprint. We have supplemented this organic growth activity with exciting product introductions in both the complex spine and degenerative categories.  Looking out to 2018, we are excited about the opportunity of our first-of-its-kind MOJAVE™ PL 3D Expandable Interbody System featuring Lamellar 3D Titanium Technology and our YUKON™ OCT Spinal System that can be used with the PALO ALTO Cervical Static Corpectomy Cage System, the first and only static corpectomy cage in the world to receive a cervical 510(k) clearance. We also announced an important strategic collaboration with Brainlab, one of the world's leading imaging and navigation companies, that we believe will represent additional implant sales opportunities in the second half of 2018.  Our Brainlab collaboration will complement our recent launches of the BACS^® platform and the EVEREST^® Minimally Invasive XT Spinal System.”

Mr. Major continued, "We remain confident in our ability to drive above-market growth in the U.S., fueled by our continued focus on leading the spine market by introducing new and innovative spinal implant solutions to help surgeons care for patients around the world who suffer from debilitating spinal pathologies. We have introduced our 2018 guidance expectations for revenue growth of 9% to 10% with improved profitability."

*Fourth Quarter 2017 Financial Results*

    *Three Months Ended December 31,* * * *Increase / Decrease*
*($,thousands)*     *2017*   *2016* * * *$ Change* *% Change* *% Change*
            *(as reported)* * (constant currency)*
United States   $ 51,856 $ 47,669   $ 4,187 8.8 % 8.8 %
International   $ 15,945 $ 14,122   $ 1,823 12.9 % 9.8 %
*Total Revenue:*   *$* *67,801* *$* *61,791* * * *$* *6,010* *9.7* *%* *9.0* *%*

Total revenue for the fourth quarter of 2017 increased $6.0 million, or 9.7%, to $67.8 million, compared to $61.8 million for the fourth quarter of 2016. Total revenue increased 9% year-over-year on a constant currency basis. The increase in revenue was primarily driven by higher sales volume from domestic new surgeon users and newer product offerings, and increased set investments by our distribution partners in Australia and Denmark. 

Revenue in the United States increased $4.2 million, or 8.8% year-over-year, to $51.9 million, and international revenue increased $1.8 million, or 12.9% year-over-year, to $15.9 million. Fourth quarter 2017 international revenue increased 10% year-over-year on a constant currency basis. Foreign currency exchange positively impacted fourth quarter international revenue by $0.4 million, representing approximately 73 basis points of 2017 international growth year-over-year.

The following table represents domestic revenue by procedure category. 

    *Three Months Ended December 31,* * * *Increase / Decrease*
*($,thousands)*     *2017*   *2016* * * *$ Change* *% Change*
Complex Spine   $ 20,004 $ 17,934   $ 2,070 11.5 %
Minimally Invasive     8,906   8,058     848 10.5 %
Degenerative     22,946   21,677     1,269 5.9 %
*U.S Revenue:*   *$* *51,856* *$* *47,669* * * *$* *4,187* *8.8* *%*

By procedure category, U.S. revenue in the Company’s complex spine, MIS and degenerative categories represented 38.6%, 17.2% and 44.2% of U.S. revenue, respectively, for the three months ended December 31, 2017.

Gross profit for the fourth quarter of 2017 increased 13.6% to $43.6 million, compared to $38.4 million for the fourth quarter of 2016.  Gross margin was 64.3% for the fourth quarter of 2017, compared to 62.1% for the prior year period. Gross profit includes amortization expense on investments in surgical instruments of $3.6 million, or 5.3% of sales, for the three months ended December 31, 2017, compared to $3.6 million, or 5.8% of sales, for the comparable period last year.

Operating expenses for the fourth quarter of 2017 increased $4.7 million, or 9.9%, to $52.5 million, compared to $47.7 million for the fourth quarter of 2016. The increase in operating expenses was driven primarily by a $4.9 million increase in sales and marketing expenses, compared to the comparable period last year.  The Company increased the number of domestic sales agencies who represent our products in the United States by nine agencies to a total of 109 independent sales agencies, an increase of 9% sequentially.  In addition, the Company’s U.S. and non-U.S. direct sales employees remained flat at 158 employees, despite active management of this group. 

Loss from operations for the fourth quarter of 2017 decreased $0.5 million to $8.9 million compared to a loss from operations of $9.4 million for the comparable period last year. Loss from operations included intangible amortization of $0.2 million for the three months ended December 31, 2017, compared to $2.6 million for the comparable period last year.  The Company recorded approximately $1.4 million in non-recurring accruals primarily reflecting legal and administrative expenses updated in 2018 and inventory adjustments.

Total other expenses for the fourth quarter of 2017 decreased $1.6 million to $1.5 million, compared to $3.1 million last year. The decrease in other expense, net, was primarily attributable to a unrealized gain of $0.3 million from foreign currency remeasurement on intercompany payable balances, compared to unrealized loss of $1.3 million in the comparable period last year.   

Net loss for the fourth quarter of 2017 was $8.7 million, or $0.20 per diluted share, compared to a loss of $12.5 million, or $0.30 per diluted share, for the fourth quarter of 2016. 

*Fiscal Year 2017 Financial Results*

    *Year Ended December 31,* * * *Increase / Decrease*
*($ in,thousands)*     *2017*   *2016* * * *$ Change* *% Change* *% Change*
            *(as reported)* * (constant currency)*
United States   $ 197,312 $ 181,078   $ 16,234 9.0 % 9.0 %
International   $ 60,719 $ 55,556   $ 5,163 9.3 % 9.7 %
*Total Revenue:*   *$* *258,031* *$* *236,634* * * *$* *21,397* *9.0* *%* *9.1* *%*

For the fiscal year 2017, total revenue increased $21.4 million, or 9.0%, to $258.0 million, compared to $236.6 million for the fiscal year 2016. Total revenue increased 9.1% year-over-year on a constant currency basis. U.S. revenue increased $16.2 million, or 9.0%, to $197.3 million, compared to $181.1 million last year. International revenue increased $5.2 million, or 9.3%, to $60.7 million, compared to $55.6 million last year. International revenue increased 9.7% year-over-year on a constant currency basis.

The following table represents domestic revenue by procedure category:

    *Year Ended December 31,* * * *Increase / Decrease*
*($,thousands)*     *2017*   *2016* * * *$ Change* *% Change*
Complex Spine   $ 77,529 $ 71,915   $ 5,614 7.8 %
Minimally Invasive     33,257   28,711   $ 4,546 15.8 %
Degenerative     86,526   80,452   $ 6,074 7.5 %
*U.S Revenue:*   *$* *197,312* *$* *181,078* * * *$* *16,234* *9.0* *%*

Sales in our complex spine, MIS and degenerative categories represented 39.3%, 16.9% and 43.9% of U.S. revenue, respectively, for the fiscal year 2017.

As of December 31, 2017, we had cash and cash equivalents of $24.0 million as compared to $45.5 million as of December 31, 2016. We had working capital of $99.6 million as of December 31, 2017 as compared to $115.9 million as of December 31, 2016.

At December 31, 2017, outstanding long-term indebtedness included the carrying value of the Convertible Senior Notes of $39.2 million and the capital lease obligation of $33.8 million. The Company had unused capacity on its revolving credit facility of $49.0 million and no borrowings outstanding as of December 31, 2017.

*2018 Outlook*

The Company is providing fiscal year 2018 revenue guidance expectations of:

· Total revenue on an as reported basis in the range of $280.0 million to $284.0 million, representing growth of 9% to 10% year-over-year, compared to total revenue of $258.0 million in fiscal year 2017. 

· The Company expects growth in its U.S. business of approximately 10% to 11% year-over-year in 2018.
· The Company expects growth in its International business of approximately 5% to 7% year-over-year in 2018.
· Assuming current currency rates remain similar for the rest of the year, the Company expects currency to have a positive impact on total revenue in 2018 of approximately $2 million.

The Company is providing fiscal year 2018 guidance expectations for net loss and Adjusted EBITDA. The Company expects:

· Total net loss of $34.0 million to $30.0 million, compared to net loss of $37.1 million in fiscal year 2017.
· Adjusted EBITDA benefit in the range of $4.0 million to $8.0 million, compared to Adjusted EBITDA loss of $740,000 in fiscal year 2017.

*Conference Call*

Management will host a conference call at 5:00 p.m. Eastern Time on February 28th to discuss the results of the fourth quarter and fiscal year 2017, and to host a question and answer session. Those who would like to participate may dial 844-579-6824 (734-385-2616 for international callers) and provide access code 3754359 approximately 10 minutes prior to the start of the call. A live webcast of the call will also be provided on the investor relations section of the Company's website at http://Investors.K2M.com/.

For those unable to participate, a replay of the call will be available for two weeks at 855-859-2056 (404-537-3406 for international callers); access code 3754359. The webcast will be archived on the investor relations section of the Company's website.

*About K2M Group Holdings, Inc.*

K2M Group Holdings, Inc. is a global leader of complex spine and minimally invasive solutions focused on achieving three-dimensional Total Body Balance. Since its inception, K2M has designed, developed, and commercialized innovative complex spine and minimally invasive spine technologies and techniques used by spine surgeons to treat some of the most complicated spinal pathologies. K2M has leveraged these core competencies into Balance ACS^®, a platform of products, services, and research to help surgeons achieve three-dimensional spinal balance across the axial, coronal, and sagittal planes, with the goal of supporting the full continuum of care to facilitate quality patient outcomes. The Balance ACS platform, in combination with the Company's technologies, techniques and leadership in the 3D-printing of spinal devices, enable K2M to compete favorably in the global spinal surgery market. For more information, visit www.K2M.com and connect with us on Facebook, Twitter, Instagram, LinkedIn and YouTube.

*Forward-Looking Statements*

This press release contains forward-looking statements that reflect current views with respect to, among other things, operations and financial performance.  Forward-looking statements include all statements that are not historical facts such as our statements about our expected financial results and guidance and our expectations for future business prospects.  In some cases, you can identify these forward-looking statements by the use of words such as, “outlook,” “guidance,” “believes,” “expects,” “potential,” “continues,” “may,” “will,” “should,” “could,” “seeks,” “predicts,” “intends,” “plans,” “estimates,” “anticipates” or the negative version of these words or other comparable words.  Such forward-looking statements are subject to various risks and uncertainties including, among other things: our ability to achieve or sustain profitability in the future; our ability to demonstrate to spine surgeons the merits of our products and retain their use of our products; pricing pressures and our ability to compete effectively generally in our industry; collaboration and consolidation in hospital purchasing; inadequate coverage and reimbursement for our products from third-party payers; lack of long-term clinical data supporting the safety and efficacy of our products; dependence on a limited number of third-party suppliers; our ability to maintain and expand our network of direct sales employees, independent sales agencies and international distributors and their level of sales or distribution activity with respect to our products; proliferation of physician-owned distributorships in the industry; decline in the sale of certain key products; loss of key personnel; our ability to enhance our product offerings through research and development; our ability to manage expected growth; our ability to successfully acquire or invest in new or complementary businesses, products or technologies; our ability to educate surgeons on the safe and appropriate use of our products; costs associated with high levels of inventory; impairment of our goodwill and intangible assets; disruptions to our corporate headquarters and operations facilities or critical information technology systems, distributors or surgeon users; our ability to ship a sufficient number of our products to meet demand; our ability to strengthen our brand; fluctuations in insurance cost and availability; our ability to comply with extensive governmental regulation within the United States and foreign jurisdictions; our ability  to maintain or obtain regulatory approvals and clearances within the United States and foreign jurisdictions; voluntary corrective actions by us or our distribution or other business partners or agency enforcement actions; recalls or serious safety issues with our products; enforcement actions by regulatory agencies for improper marketing or promotion; misuse or off-label use of our products; delays or failures in clinical trials and results of clinical trials; legal restrictions on our procurement, use, processing, manufacturing or distribution of allograft bone tissue; negative publicity concerning methods of tissue recovery and screening of donor tissue; costs and liabilities relating to environmental laws and regulations; our failure or the failure of our agents to comply with fraud and abuse laws; U.S. legislative or Food and Drug Administration regulatory reforms; adverse effects of medical device tax provisions; potential tax changes in jurisdictions in which we conduct business; our ability to generate significant sales; potential fluctuations in sales volumes and our results of operations over the course of the year; uncertainty in future capital needs and availability of capital to meet our needs; our level of indebtedness and the availability of borrowings under our credit facility; restrictive covenants and the impact of other provisions in the indenture governing our convertible  senior notes and our credit facility;  continuing worldwide economic instability; our ability to protect our intellectual property rights; patent litigation and product liability lawsuits; damages relating to trade secrets or non-competition or non-solicitation agreements; risks associated with operating internationally; fluctuations in foreign currency exchange rates; our ability to comply with the Foreign Corrupt Practices Act and similar laws; our ability to implement and maintain effective internal control over financial reporting; potential volatility in our stock price; our lack of current plans to pay cash dividends; increased costs and additional regulations and requirements as a result of no longer qualifying as an emerging growth company as of December 31, 2017; potential dilution by the future issuances of additional common stock in connection with our incentive plans, acquisitions or otherwise; anti-takeover provisions in our organizational documents and our ability to issue preferred stock without shareholder approval; potential limits on our ability to use our net operating loss carryforwards; and other risks and uncertainties, including those described under the section entitled “Risk Factors” in our most recent Annual Report on Form 10-K filed with the SEC and our Quarterly Report filed with the SEC on November 1, 2017, as such factors may be updated from time to time in our periodic filings with the SEC, which are accessible on the SEC's website at www.sec.gov.  Accordingly, there are or will be important factors that could cause actual outcomes or results to differ materially from those indicated in these statements.  These factors should not be construed as exhaustive and should be read in conjunction with the other cautionary statements that are included in this release and our filings with the SEC.

We operate in a very competitive and challenging environment.  New risks and uncertainties emerge from time to time, and it is not possible for us to predict all risks and uncertainties that could have an impact on the forward-looking statements contained in this release.  We cannot assure you that the results, events and circumstances reflected in the forward-looking statements will be achieved or occur, and actual results, events or circumstances could differ materially from those described in the forward-looking statements.

The forward-looking statements made in this press release relate only to events as of the date on which the statements are made.  We undertake no obligation to publicly update or review any forward-looking statement, whether as a result of new information, future developments or otherwise, except as required by law.  We may not actually achieve the plans, intentions or expectations disclosed in our forward-looking statements and you should not place undue reliance on our forward-looking statements. Unless specifically stated otherwise, our forward-looking statements do not reflect the potential impact of any future acquisitions, mergers, dispositions, joint ventures, investments or other strategic transactions we may make.

*K2M GROUP HOLDINGS, INC.*
*CONDENSED CONSOLIDATED BALANCE SHEETS*
*(In Thousands, Except Share and Per Share Data)*
 
    *December 31,*
    *2017*   *2016*
*ASSETS*        
Current assets:        
Cash and cash equivalents   $ 23,964       $ 45,511    
Accounts receivable, net   50,474       46,430    
Inventory, net   71,424       61,897    
Prepaid expenses and other current assets   7,842       6,147    
Total current assets   153,704       159,985    
Property, plant and equipment, net   49,200       50,714    
Surgical Instruments, net   26,250       24,810    
Goodwill   121,814       121,814    
Intangible assets, net   18,899       22,758    
Other assets   3,260       3,444    
Total assets   $ 373,127       $ 383,525    
*LIABILITIES AND STOCKHOLDERS’ EQUITY*        
Current liabilities:        
Current maturities under capital lease obligation   $ 1,122       $ 973    
Accounts payable   20,495       15,367    
Accrued expenses   22,233       15,673    
Accrued payroll liabilities   10,214       12,068    
Total current liabilities   54,064       44,081    
Convertible senior notes   39,176       36,894    
Capital lease obligation, net of current maturities   33,812       34,933    
Deferred income taxes, net   3,360       5,017    
Other liabilities   316       1,032    
Total liabilities   130,728       121,957    
         
Stockholders’ equity:        
Common stock, $0.001 par value, 750,000,000 shares authorized; 43,389,576 and 42,291,352 shares issued and 43,373,611 and 42,282,741 shares outstanding, respectively   43       42    
Additional paid-in capital   491,012       474,512    
Accumulated deficit   (249,221 )     (211,081 )  
Accumulated other comprehensive income (loss)   876       (1,771 )  
Treasury stock, at cost, 15,965 and 8,611 shares, respectively   (311 )     (134 )  
Total stockholders’ equity   242,399       261,568    
Total liabilities and stockholders’ equity   $ 373,127       $ 383,525    

*K2M GROUP HOLDINGS, INC.*
*CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS*
*(In Thousands, Except Share and Per Share Data)*
 
    *Three Months Ended
 December 31,*   *Year Ended
 December 31,*
      *2017*     *2016*     *2017*     *2016*
Revenue   $ 67,801       $ 61,791       $ 258,031       $ 236,634    
Cost of revenue     24,223         23,431         88,649         82,178    
Gross profit     43,578         38,360         169,382         154,456    
Operating expenses:                
Research and development     6,077         5,558         22,247         21,547    
Sales and marketing     32,101         27,244         123,374         111,376    
General and administrative     14,281         14,921         57,218         56,264    
Total operating expenses     52,459         47,723         202,839         189,187    
Loss from operations     (8,881 )       (9,363 )       (33,457 )       (34,731 )  
Other expense, net:                
Foreign currency transaction gain (loss)     284         (1,331 )       1,802         (2,430 )  
Interest expense     (1,753 )       (1,720 )       (6,964 )       (4,425 )  
Total other expense, net     (1,469 )       (3,051 )       (5,162 )       (6,855 )  
Loss before income taxes     (10,350 )       (12,414 )       (38,619 )       (41,586 )  
Income tax (benefit) expense     (1,602 )       53 )       (1,474 )       74 )  
Net loss   $   (8,748 )     $   (12,467 )     $   (37,145 )     $   (41,660 )  
Net loss per share:                
Basic and diluted   $ (0.20 )     $ (0.30 )     $ (0.87 )     $ (1.00 )  
Weighted average common shares outstanding:                
Basic and diluted     43,070,509         41,995,284         42,739,525         41,729,013    

*K2M GROUP HOLDINGS, INC.*
*CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS*
*(In Thousands)*
 
    *Year Ended
 December 31,*
    *2017*   *2016*
*Operating activities*                
Net loss   $ (37,145 )     $ (41,660 )  
Adjustments to reconcile net loss to net cash used in operating activities:        
Depreciation and amortization   26,785       29,212    
Provision for inventory reserve   4,371       5,572    
Provision for allowance for doubtful accounts   347       68    
Stock-based compensation   5,932       6,956    
Accretion of discounts and amortization of issuance costs of convertible senior notes   2,358       1,604    
Deferred income taxes   (1,657 )     (33 )  
Other   (14 )     —    
Changes in operating assets and liabilities:        
Accounts receivable   (2,834 )     (9,381 )  
Inventory   (6,965 )     (3,439 )  
Prepaid expenses and other assets   (9,741 )     (10,256 )  
Accounts payable, accrued expenses, and accrued payroll liabilities   5,750       8,059    
Net cash used in operating activities   (12,813 )     (13,298 )  
*Investing activities*        
Purchase of surgical instruments   (11,066 )     (12,275 )  
Purchase of property, plant and equipment   (3,920 )     (17,439 )  
Changes in cash restricted for leasehold improvements   61       6,608    
Purchase of intangible assets   (2,958 )     (1,307 )  
Net cash used in investing activities   (17,883 )     (24,413 )  
*Financing activities*        
Borrowings on bank line of credit   —       19,500    
Payments on bank line of credit   —       (19,500 )  
Proceeds from issuance of convertible senior notes, net issuance of costs   —       47,108    
Principal payments under capital lease   (973 )     (219 )  
Issuances and exercise of stock-based compensation benefit plans, net of income tax   9,397       2,244    
Net cash provided by financing activities   8,424       49,133    
Effect of exchange rate changes on cash and cash equivalents   725       (557 )  
Net change in cash and cash equivalents   (21,547 )     10,865    
Cash and cash equivalents at beginning of period   45,511       34,646    
Cash and cash equivalents at end of period   $ 23,964       $ 45,511    
         
*Significant non-cash investing activities*        
Leasehold improvements, including property under capital lease   $ —       $ 171    
Additions to property, plant and equipment   $ 250       $ —    
         
*Significant non-cash financing activities*        
Capital lease obligation   $ —       $ 1,708    
Accretion of discount on convertible senior notes   $ 2,281       $ 807    
*Cash paid for:*        
Income taxes   $ 168       $ 159    
Interest   $ 2,231       $ 382    

*K2M GROUP HOLDINGS, INC.*
*Reconciliation of GAAP to Non-GAAP Measures*
*(Unaudited)*
* (In Thousands)*

*Use of Non-GAAP Financial Measures*

This press release includes the non-GAAP financial measures of revenue in constant currency, Adjusted Gross Profit, and Adjusted EBITDA.

The Company presents these non-GAAP measures because it believes these measures are useful indicators of the Company’s operating performance.  Management uses these non-GAAP measures principally as a measure of the Company's operating performance and believes that these measures are useful to investors because they are frequently used by analysts, investors and other interested parties to evaluate companies in the Company’s industry.  The Company also believes that these measures are useful to its management and investors as a measure of comparative operating performance from period to period.

Constant currency information compares results between periods as if exchange rates had remained constant period-to-period.  We calculate constant currency by converting the prior-year results using current-year foreign currency exchange rates.

Adjusted Gross Profit represents Gross Profit less amortization expense of surgical instruments.  The Company presents Adjusted Gross Profit because it believes it is a useful measure of the Company's gross profit and operating performance because the measure is not burdened by the timing impact of instrument purchases and related amortization. 

Adjusted EBITDA represents net loss plus interest expense, income tax expense, depreciation and amortization, stock-based compensation expense and foreign currency transaction (gain) loss.

The Company presents Adjusted EBITDA because it believes it is a useful indicator of the Company’s operating performance.  Management uses Adjusted EBITDA principally as a measure of the Company’s operating performance and for planning purposes, including the preparation of the Company’s annual operating budget and financial projections. 

Adjusted EBITDA is a non-GAAP financial measure and should not be considered as an alternative to net loss as a measure of financial performance or cash flows from operations as a measure of liquidity, or any other performance measure derived in accordance with GAAP and it should not be construed as an inference that the Company’s future results will be unaffected by unusual or non-recurring items.  In addition, Adjusted EBITDA is not intended to be a measure of free cash flow for management’s discretionary use, as it does not reflect certain cash requirements such as tax payments, debt service requirements, capital expenditures and certain other cash costs that may recur in the future.  Adjusted EBITDA contains certain other limitations, including the failure to reflect the Company’s cash expenditures, cash requirements for working capital needs and cash costs to replace assets being depreciated and amortized.  In evaluating Adjusted EBITDA, you should be aware that in the future the Company may incur expenses that are the same as or similar to some of the adjustments in this presentation.  The Company’s presentation of Adjusted EBITDA should not be construed to imply that the Company’s future results will be unaffected by any such adjustments.  Management compensates for these limitations by primarily relying on its GAAP results in addition to using Adjusted EBITDA supplementally.  The Company’s definition of Adjusted EBITDA is not necessarily comparable to other similarly titled captions of other companies due to different methods of calculation.

The following table presents reconciliations of gross profit to adjusted gross profit and net loss to Adjusted EBITDA for the periods presented.

$ in thousands   *Three Months Ended December 31,*   * Year Ended December 31,*
    *2017*   *2016*   *2017*   *2016*
*Reconciliation from Gross Profit to Adjusted Gross Profit*                
*Gross Profit*   $ 43,578     $ 38,360     $ 169,382     $ 154,456  
Surgical instrument amortization   3,605     3,575     14,130     13,725  
Adjusted Gross Profit (a Non-GAAP Measure)   $ 47,183     $ 41,935     $ 183,512     $ 168,181  

    *Three Months Ended December 31,*   *Year Ended December 31,*
    *2017*   *2016*   *2017*   *2016*
*Reconciliation from Net Loss to Adjusted EBITDA*                
Net loss   $ (8,748 )     $ (12,467 )     $ (37,145 )     $ (41,660 )  
Interest expense   1,753       1,720       6,964       4,425    
Income tax (benefit) expense   (1,602 )     53       (1,474 )     74    
Depreciation and amortization   5,361       7,760       26,785       29,212    
Stock-based compensation expense   1,610       1,575       5,932       6,956    
Foreign currency transaction (gain) loss   (284 )     1,331       (1,802 )     2,430    
Adjusted EBITDA (a Non-GAAP Measure)   $ (1,910 )     $ (28 )     $ (740 )     $ 1,437    

The following table presents a reconciliation of net loss to Adjusted EBITDA for our 2018 guidance:

    *Year Ended*
*December 31,*
    *2018*
Net loss   $ (32,000 )
Interest expense   8,500  
Income tax expense   100  
Depreciation and amortization   23,000  
Stock-based compensation expense   6,400  
Foreign currency transaction gain   —
 
Adjusted EBITDA   $ 6,000  
       

The reconciliation assumes the mid-point of the Adjusted EBITDA range and the mid-point of each component of the reconciliation, corresponding to guidance of $4.0 million to $8.0 million for 2018. 

 CONTACT: Investor Contact:
Westwicke Partners on behalf of K2M Group Holdings, Inc.
Mike Piccinino, CFA
443-213-0500
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